By Leo Schindel
Unforeseen Reactions to fashionable Therapeutics: Antibiotics discusses the side-effects of antibiotics, particularly the allergies of the surface and mucous membranes to penicillin. This ebook comprises 12 chapters that handle the categorical organ response to penicillin and the problems of the gastro-intestinal tract after ingestion of chloramphenicol. the various subject matters lined within the publication are the inhibition of the bone marrow functionality and blood alterations after receiving doses of chloramphenicol; lesions of the outside and mucous membranes after making use of tetracyclines; adjustments within the hemopoietic approach, liver functionality, and constitution after drugs of oxy-tetracycline. different chapters care for the research of antibiotic resistant micro organism and the physiological adversarial results of neomycin. An research of the side-effects of erythromycin is supplied. The concluding chapters describe the nephrotoxic results of bacitracin and the epidermal results of fumagillin. The ebook promises worthwhile info to medical professionals, pharmacologists, scholars, and researchers.
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Extra info for Unexpected Reactions to Modern Therapeutics. Antibiotics
30 UNEXPECTED REACTIONS TO MODERN THERAPEUTICS One cannot better formulate the reactions to penicillin than Kern and his associates have done in their survey. These authors found that penicillin is capable of producing allergies more than any other drug. The symptoms of penicillin sensitivity comprise all those reactions known in the field of allergy. The most serious complication and the greatest danger due to penicillin is anaphylactic shock which may sometimes be fatal. Among other reactions the most frequent ones are: dermatitis, urticaria, erythema nodosum and multiform exfoliative bullous dermatitis, serum-sickness-like syndromes, skin haemorrhages, agranulocytosis, lupus erythematosus disseminatus and periarteritis nodosa.
There is no consensus of opinion as to the influence on the prothrombin time after penicillin. There are reports both of a shortened as well as of a prolonged prothrombin time. The shortened coagulation time in patients who had received penicillin was one of the first general toxic signs which were not based on allergies. This fact was confirmed by Moldovski and associates. Fleming and associates, however, published precisely the contrary. Macht states that various penicillins show a thromboplastic quality increasing at the following sequence: the lowest in penicillin F, followed by penicillin G, Κ and the highest in penicillin X.
Kile, R. L. (1950) Contact dermatitis from procaine penicillin, Archives Dermat. and Syph. 61, 484. Kitchen, D. , Rein, C. , Thomas, E. , and Spoor, H. J. (1951) Reaction to penicillin. Am. J. Syph. and Ven. Dis. 35, 578. Kline, C. L. and Highsmith, L. S. (1948) Toxic psychosis resulting from penicillin. Ann. Int. Med. 28, 1057. Kolb, C. and Gray, S. J. (1946) Peripheral neuritis as a complication of penicillin therapy. A. 132, 323. Kolodny, M. H. and Denhoff, E. (1946) Reaction in penicillin therapy.
Unexpected Reactions to Modern Therapeutics. Antibiotics by Leo Schindel