By Marion E. Reid
The Blood workforce Antigen FactsBook ― winner of a 2013 hugely counseled BMA scientific booklet Award for inner medication ― has been a necessary source within the hematology, transfusion and immunogenetics fields for the reason that its first book within the past due 1990s.The third edition of The Blood crew Antigen FactsBook has been thoroughly revised, up to date and increased to hide all 33 blood team structures. It blends clinical historical past and medical functions and offers busy researchers and clinicians with at-a-glance details on over 330 blood team antigens, together with background and knowledge on terminology, expression, chromosomal task, service molecular description, features, molecular bases of antigens and phenotypes, impact of enzymes/chemicals, scientific importance, affliction institutions and key references.
- Highly recommended 2013 BMA scientific e-book Award for inner Medicine
- Includes greater than 330 entries on blood workforce antigens in person factsheets
- Offers a logical and concise catalogue constitution for every antigen in a stronger inside layout for speedy reference
- Written by three overseas specialists from the sphere of immunohematology and transfusion medicine
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The Blood crew Antigen FactsBook ― winner of a 2013 hugely recommended BMA clinical ebook Award for inner drugs ― has been a vital source within the hematology, transfusion and immunogenetics fields due to the fact its first booklet within the overdue Nineteen Nineties. The third edition of The Blood workforce Antigen FactsBook has been thoroughly revised, up to date and improved to hide all 33 blood workforce platforms.
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Extra info for The Blood Group Antigen Facts: Book
03 O49 O2–3 2 5 6 7 7 7 53GT 220CT 297AG 526CG 689GA 802G>A Arg18Leu Pro74Ser – Arg176Gly Gly229Asp Gly268Arg Caucasians (Many) O? 04 O50 O2–4 2 5 6 7 7 7 53GT 220CT 297AG 488CT 526CG 802G>A Arg18Leu Pro74Ser – Thr163Met Arg176Gly Gly268Arg Caucasians (Several) O? 03 O08 O3 7 7 7 467CT 804insG 1061delC Pro156Leu 269fs# 354fs# Caucasians (Rare) O? 04 O51 O4, O41 2 87_88insG 29fs56Stop Caucasians (Rare) O? 05 O52 O5 6 322C>T Gln108Stop Caucasians (Rare) O? 08 O15 O302 7 927C>A Tyr309Stop Japanese (Rare) O?
Effect of enzymes and chemicals on A1 antigen on intact RBCs Ficin/Papain Trypsin α-Chymotrypsin DTT 200 mM Acid Resistant (markedly enhanced) Resistant (markedly enhanced) Resistant (markedly enhanced) Resistant Resistant In vitro characteristics of alloanti-A1 Immunoglobulin class Optimal technique Neutralization Complement binding IgM more common than IgG RT or below Saliva from A (A1) secretors Rare Clinical significance of alloanti-A1 Transfusion reaction HDFN None to mild/delayed No Autoantibody Rare Comments Anti-A1 is found in serum from 1–2% of A2 and 25% of A2B individuals, and is a component of anti-A from group O and B people.
Cloning and characterization of DNA complementary to human UDP-GalNAc: Fuca1—2Gala1—3GalNAc transferase (histo-blood group A transferase) mRNA. J Biol Chem 265, 1146–1151. , 1990. Molecular genetic basis of the histo-blood group ABO system. Nature 345, 229–235. , 1989. ABH and related histo-blood group antigens; immunochemical differences in carrier isotypes and their distribution. Vox Sang 56, 1–20. , 2001. The ABO blood group gene: a locus of considerable genetic diversity. Transfus Med Rev 15, 177–200.
The Blood Group Antigen Facts: Book by Marion E. Reid