By Raffaele Badolato, Silvano Sozzani
Since the invention of chemokines and of chemokine receptors it has turn into glaring that expression of chemokines on the web site of irritation may well keep an eye on the composition of mobile infiltrate, thereby directing the kind of immune reaction. lately, the molecular characterization of inherited problems of immune procedure, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), that are characterised via cytoskeleton/adhesion defects or through altered reaction of chemokine receptors has contributed to clarifying the most important gamers of immune reaction in general body structure and in affliction. This booklet, which bargains with the outline of the position of chemokines in immune reaction and underlines capability pursuits of therapeutical intervention, deals a sequence of contributions of the main hard facets of lymphocyte migration in homeostasis and in disease.
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Because the discovery of chemokines and of chemokine receptors it has turn into obtrusive that expression of chemokines on the website of irritation may well keep watch over the composition of mobile infiltrate, thereby directing the kind of immune reaction. lately, the molecular characterization of inherited issues of immune procedure, (e.
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Extra info for Lymphocyte Trafficking in Health and Disease
A particular role in lymphocyte homing is ascribed to the interactions between α4β7 integrin with its vascular ligand MAdCAM-1, which act as a brake during naïve lymphocyte interactions in the high endothelial venules (HEVs) of the Peyer’s patches . α4β7 is expressed at low levels on naïve T cells, so that L-selectin is required for efficient tethering. In fact, α4β7 integrin is required to slow L-selectininitiated rolling sufficiently to allow activation and engagement of LFA-1 for firm arrest .
Expression of cutaneous lymphocyte antigen (CLA), a fucosyltransferase VII (FucT-VII)-dependent carbohydrate modification of PSGL-1, is closely correlated with interactions between PSGL-1 and Eselectin. It has been previously demonstrated that FucT-VII expression is high in Th1 cells, while Th2 lymphocytes expresses high levels of FucT-IV, but not FucTVII . Moreover, Th1 cells, but not Th2 cells, are able to bind to P-selectin and E-selectin. Experiments performed in mice with targeted deletions of the FucT-IV and FucT-VII loci have established that absence of FucT-VII yields a severe attenuation of lymphocyte migration to secondary lymphoid organs and to sites of cutaneous inflammation .
Immunity 12: 121–127 Baggiolini M (2001) Chemokines in pathology and medicine. J Intern Med 250: 91–104 Thelen M (2001) Dancing to the tune of chemokines. Nat Immunol 2: 129–134 Meili R, Firtel RA (2003) Two poles and a compass. Cell 114: 153–156 Rot A, von Andrian UH (2004) Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol 22: 891–928 Biology of chemokines 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 Curnock AP, Logan MK, Ward SG (2002) Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
Lymphocyte Trafficking in Health and Disease by Raffaele Badolato, Silvano Sozzani