By Balwinder, M.D. Singh
Disseminated intravascular coagulation is a devastating syndrome characterized by means of the systemic activation of frequent activation of the coagulation cascade and thrombosis, which can bring about critical bleeding and will bring about organ failure. contemporary reviews have proven that the occurrence of DIC is lowering, particularly in males. regardless of the advancements in future health care supply, the morbidity and mortality because of DIC continues to be very excessive. This e-book offers an incredible well timed replace at the scientific manifestations, vital chance components, and therapy options for DIC, and offers in-depth details on pathophysiological points and numerous diagnostic ratings used to diagnose DIC.
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Extra info for Disseminated Intravascular Coagulation (DIC): Clinical Manifestations, Diagnosis and Treatment Options
Thromb Res. 1994;74:355–367  Singletary EM, Rochman AS, Bodmer JC, Holstege CP. Envenomation. 2005;89:1195–1224. 40 Akhilesh Kumar Tiwari, Rajiv Ratan Singh, Rishi Raj Sanjay et al.  Jae Woo Jung, Eun Ju Jeon, Jeong Wook Kim, Jae Chol Choi, Jong Wook Shin, Jae Yeol Kim, In Won Park,and Byoung Whui Choi. A fatal case of Intravascular coagulation after Bee sting acupuncture. Allergy Asthma Immunol Res. 2012 March; 4: 107–109.  Petroianu G, Liu J, Helfrich U, Maleck W, Rüfer R. Phospholipase A2induced coagulation abnormalities after bee sting.
Alternatively, TM may antagonize HMGB1 by enhancing thrombin-mediated proteolytic degradation of HMGB1 . Recombinant TM for Treatment of DIC The recombinant human soluble TM (rhsTM) derived from Chinese hamster ovary (CHO) cells, is composed of the extracellular domain of TM . Similar to membrane-bound native TM, rhsTM retains the ability to bind to thrombin and APC. Administration of rhsTM has been shown to protect rats from tissue factor and endotoxin-induced DIC or lung injury [50-52].
Disseminated Intravascular coagulation. 2004; 344:13-21. Takemitsu T, Wada H, Hatada T, Ohmori Y, Ishikura K, Takeda T, Sugiyama T, Yamada N, Maruyama K, Katayama N, Isaji S, Shimpo H, Kusunoki M, Nobori T. Prospective evaluation of three different diagnostic criteria for disseminated intravascular coagulation. Thromb Haemost. 2011;105:40-4. Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M; Scientific Subcommittee on Disseminated Intravascular Coagulation [DIC] of the International Society on Thrombosis and Haemostasis [ISTH].
Disseminated Intravascular Coagulation (DIC): Clinical Manifestations, Diagnosis and Treatment Options by Balwinder, M.D. Singh