
By Martin S. Tallman, Leo I. Gordon
ISBN-10: 0585385718
ISBN-13: 9780585385716
ISBN-10: 0792382064
ISBN-13: 9780792382065
There isn't any box of medication during which advances in treatment have been so heavily associated with a greater realizing of molecular medication than within the region of hematologic malignancies. Diagnostic and healing Advances in Hematologic Malignancies will supply practitioners and educational clinicians with a greater figuring out of the continuously evolving suggestions during this region.
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J. Clin. Invest. 93, 1564–1570. 32. , and Ratcliffe, P. (1995) Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents. Am. J. Physiol. 268, C1362–C1368. 33. , and Boulton, M. (1994) Oxygen regulation of TGF `1 mRNA in human hepatoma (HEP G2) cells. Biochem. Mol. Biol. Int. 34, 639–644. 34. Sampson, L. and Chaplin, D. (1996) The influence of oxygen and carbon dioxide tension on the production of TNF _ by activated macrophages. Br. J. Cancer 74(Suppl.
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Large variations in vessel densities have been demonstrated during tumor growth (16), and hypoxia is present not only in large tumors with necrosis, but also in small tumors (19). This is related in part to the growth site, tumor cell properties (respiration rates and cell density), and to variations in vascularization patterns (20,21). Tissue oxygenation is the result of the O2 blood supply, diffusion in the extravascular space, and respiration rate of the cells. The availability of oxygen represents the amount of oxygen carried by the blood per unit of time to a given tissue (16).
Diagnostic & Therapeutic Advances in Hematologic Malignancies (Cancer Treatment and Research) by Martin S. Tallman, Leo I. Gordon
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