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Read e-book online Diagnostic & Therapeutic Advances in Hematologic PDF

5 April 2018 adminHematology

By Martin S. Tallman, Leo I. Gordon

ISBN-10: 0585385718

ISBN-13: 9780585385716

ISBN-10: 0792382064

ISBN-13: 9780792382065

There isn't any box of medication during which advances in treatment have been so heavily associated with a greater realizing of molecular medication than within the region of hematologic malignancies. Diagnostic and healing Advances in Hematologic Malignancies will supply practitioners and educational clinicians with a greater figuring out of the continuously evolving suggestions during this region.

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Additional resources for Diagnostic & Therapeutic Advances in Hematologic Malignancies (Cancer Treatment and Research)

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J. Clin. Invest. 93, 1564–1570. 32. , and Ratcliffe, P. (1995) Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents. Am. J. Physiol. 268, C1362–C1368. 33. , and Boulton, M. (1994) Oxygen regulation of TGF `1 mRNA in human hepatoma (HEP G2) cells. Biochem. Mol. Biol. Int. 34, 639–644. 34. Sampson, L. and Chaplin, D. (1996) The influence of oxygen and carbon dioxide tension on the production of TNF _ by activated macrophages. Br. J. Cancer 74(Suppl.

Douglas, J. , Granger, H. , and Ziche, M. (1996) Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium. Am. J. Physiol. 270, H411–H415. 75. Jenkins, D. , Charles, I. , Thomsen, L. , Moss, D. , Holmes, L. , Baylis, S. , et al. (1995) Roles of nitric oxide in tumor growth. Proc. Natl. Acad. Sci. USA 92, 4392–4396. 76. , and Isner, J. M. (1997) Reciprocal relation between VEGF and NO in the regulation of endothelial integrity. Nature Med. 3, 879–886. 77. Tuder, R. , Flook, B.

Large variations in vessel densities have been demonstrated during tumor growth (16), and hypoxia is present not only in large tumors with necrosis, but also in small tumors (19). This is related in part to the growth site, tumor cell properties (respiration rates and cell density), and to variations in vascularization patterns (20,21). Tissue oxygenation is the result of the O2 blood supply, diffusion in the extravascular space, and respiration rate of the cells. The availability of oxygen represents the amount of oxygen carried by the blood per unit of time to a given tissue (16).

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Diagnostic & Therapeutic Advances in Hematologic Malignancies (Cancer Treatment and Research) by Martin S. Tallman, Leo I. Gordon


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