By Craig S. Kitchens MD, Barbara A Konkle MD, Craig M. Kessler MD
2014 BMA clinical e-book Awards hugely recommended in inner medication classification!
A unique scientific focus makes Consultative Hemostasis and Thrombosis, third Edition your go-to consultant for fast, sensible solutions on coping with the whole variety of bleeding and clotting problems. Emphasizing real-world difficulties and options, Dr. Craig S. Kitchens, Dr. Barbara A. Konkle, and Dr. Craig M. Kessler offer all the scientific information you need to make optimum judgements on behalf of your sufferers and advertise the very best outcomes.
- Efficiently lookup concise descriptions of every condition, its linked signs, laboratory findings, prognosis, differential prognosis, and treatment.
- Get the newest information
- Apply today’s most modern therapies, together with those who are fast changing into general during this fast-changing field.
- Meet the wishes of particular sufferer groups with a brand new bankruptcy on Bleeding and the administration of Hemorrhagic problems in Pregnancy and an greatly up-to-date bankruptcy on Thrombosis and Cancer.
- Zero in on key information with a brand new ordinary layout, and all-new full-color format, plentiful laboratory protocols, and at-a-glance tables and charts throughout.
- Access the full textual content and illustrations online - totally searchable - at www.expertconsult.com.
on sizzling issues akin to Disseminated Intravascular Coagulation, Thrombophilia, scientific and Laboratory overview and administration, Thrombotic -Thrombocytopenic Purpura, and Heparin-Induced Thrombocytopenia.
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Additional info for Consultative Hemostasis and Thrombosis. Expert Consult - Online and Print
Circ Res 111:110–130, 2012. 23. Mehta D, Malik AB: Signaling mechanisms regulating endothelial permeability. Physiol Rev 86:279–367, 2006. 24. Aird WC: Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. Circ Res 100:158–173, 2007. 25. von Andrian UH, Mempel TR: Homing and cellular traffic in lymph nodes. Nat Rev Immunol 3:867–878, 2003. 26. Rao RM, Shaw SK, Kim M, et al: Emerging topics in the regulation of leukocyte transendothelial migration. Microcirculation 12:83–89, 2005.
Moreover, data supporting their use are derived from cohort studies, so their predictive value in individual patients is unknown. , capillaries). Circulating biomarkers for the endothelium include soluble and cell-based assays. , TABLE 3-1 Diagnostic Markers for Endothelium Marker Comments PATHOLOGY Not readily available except for skin biopsies; results from skin biopsies may not be extrapolatable to other vascular beds SOLUBLE MEDIATORS sICAM-1 sVCAM-1 sP-selectin sE-selectin sTM tPA PAI-1 VWF sEPCR Others CELL-BASED MEDIATORS CECs MPs EPCs Not specific to endothelial cells Not specific to endothelial cells Not specific to endothelial cells Specific to endothelial cells Specific to endothelial cells Not specific to endothelial cells Not specific to endothelial cells Not specific to endothelial cells Specific to endothelial cells May be quantitated and phenotyped; limited by small numbers in the blood May be quantitated and phenotyped May be quantitated and phenotyped; hematopoietic in origin MOLECULAR IMAGING Holds promise for vascular bed-specific diagnosis FLOW STUDIES The only diagnostic assays that have reached clinical mainstream CEC, Circulating endothelial cell; EPC, endothelial progenitor cell; MP, microparticle; PAI-1, plasminogen activator inhibitor 1; sEPCR, soluble endothelial protein C receptor; sICAM, soluble intercellular adhesion molecule; sTM, soluble thrombomodulin; sVCAM, soluble vascular cell adhesion molecule; tPA, tissue plasminogen activator; VWF, von Willebrand factor.
Input arises from the extracellular environment and may include any number of biochemical and biomechanical forces. Examples of biochemical mediators include growth factors, cytokines, 3 Endothelium 35 chemokines, temperature, pH, and oxygenation (Box 3-1). The major biomechanical forces are shear stress and strain. Output, or cellular phenotype, depends on the level of organization. Single endothelial cells may undergo a change in calcium flux or shape, an alteration in protein or mRNA expression, and they may migrate, proliferate, or undergo apoptosis.
Consultative Hemostasis and Thrombosis. Expert Consult - Online and Print by Craig S. Kitchens MD, Barbara A Konkle MD, Craig M. Kessler MD