
By Ying Xu, Dong Xu, Jie Liang
ISBN-10: 0387333215
ISBN-13: 9780387333212
Quantity of this two-volume series offers a finished assessment of protein constitution prediction tools and comprises protein threading, De novo tools, functions to membrane proteins and protein complexes, structure-based drug layout, in addition to constitution prediction as a platforms challenge. a chain of appendices evaluate the organic and chemical fundamentals with regards to protein constitution, desktop technology for structural informatics, and prerequisite arithmetic and facts.
Read or Download Computational Methods for Protein Structure Prediction and Modeling: Volume 2: Structure Prediction (Biological and Medical Physics, Biomedical Engineering) PDF
Similar bioinformatics books
Because the self sufficient invention of DNA sequencing by way of Sanger and by means of Gilbert 30 years in the past, it has grown from a small scale strategy in a position to examining a number of kilobase-pair of series according to day into trendy multibillion greenback undefined. This development has spurred the improvement of latest sequencing applied sciences that don't contain both electrophoresis or Sanger sequencing chemistries.
New PDF release: Plant Transposons and Genome Dynamics in Evolution
Content material: bankruptcy 1 the invention of Transposition (pages 3–13): Nina V. FedoroffChapter 2 A box advisor to Transposable parts (pages 15–40): Alan H. Schulman and Thomas WickerChapter three The Mechanism of Ac/Ds Transposition (pages 41–59): Thomas Peterson and Jianbo ZhangChapter four McClintock and Epigenetics (pages 61–70): Nina V.
Download PDF by Alexander Hillisch, R. Hilgenfeld: Modern Methods of Drug Discovery
This quantity bargains a large and interdisciplinary view of recent methods to drug discovery as utilized by pharmaceutical businesses and study institutes. It comprehensively covers proteomics, bioinformatics, screening suggestions reminiscent of high-throughput-, traditional compounds-, and NMR-based-screenings, combinatorial chemistry, compound library layout, ligand- and structure-based drug layout and pharmacokinetic methods.
Das Phänomen Leben: Grundfragen der Theoretischen Biologie - download pdf or read online
Der renommierte Tierphysiologe Heinz Penzlin behandelt in diesem Buch, das hier in zweiter Auflage vorgelegt wird, in systematischer und übersichtlicher shape die naturwissenschaftlichen Grundprinzipien, die alleLebewesen – trotz ihrer enormen Formenvielfalt – gleichermaßen kennzeichnen. Das Buch ist keine Biophilosophie, sondern richtet sich an alle, die an den wissenschaftlichen Grundlagen des Phänomens „Leben“ aus heutiger Sicht interessiert sind.
Extra info for Computational Methods for Protein Structure Prediction and Modeling: Volume 2: Structure Prediction (Biological and Medical Physics, Biomedical Engineering)
Example text
2004) performed structure prediction for all of the ORFs of Pyrococcusfuriosus, which is found in the marine sand surrounding sulfurous volcanoes and can grow at temperatures above 100a e. The microbe utilizes peptides, proteins, and some carbohydrates as carbon sources. Its entire genome is about 2 Mb in length with 2195 annotated ORFs. Out of a total of 2195 ORFs, 540 are predicted to be membrane proteins, and 753 proteins can be predicted with structures in high confidence, among which 190 ORFs cannot be detected using PSI-BLAST.
To do this, one needs to put all the atoms, backbone and side chains, into a structural model. One can use alignments with the selected templates in fold recognition to produce a 3D atomic model through homology modeling tools, such as MODELLER (Sali and Blundell, 1990), which runs a protocol ofenergy minimization and molecular dynamics simulation to refine a structural model. , 1993) to evaluate the packing and backbone conformations, the inside/outside occupancies ofhydrophobic and hydrophilic residues, and stereochemical quality of a predicted structure.
These partial structural data might be in the form of (a) residue-residue distances such as disulfides between specific cysteines, (b) specific residues involved in particular active sites, binding sites, or other functionally important sites, (c) specific residues known to be on the surface ofa protein structure, or any other information providing geometric information about specific residues in a protein structure. In addition to such information about specific residues, there are experimental techniques that can be used to generate geometric information in a systematic manner.
Computational Methods for Protein Structure Prediction and Modeling: Volume 2: Structure Prediction (Biological and Medical Physics, Biomedical Engineering) by Ying Xu, Dong Xu, Jie Liang
by John
4.2