ISBN-10: 0470714689
ISBN-13: 9780470714683
ISBN-10: 0470715162
ISBN-13: 9780470715161
Content:
Chapter 1 Chairman's starting feedback (pages 1–3): A. S. McFarlane
Chapter 2 Metabolism of 14C?Labelled Steroids (pages 4–13): C. P. Leblond
Chapter three excessive ldl cholesterol content material of Human Spleen (pages 14–16): Karl Bernhard
Chapter four The Biosynthesis of Radioactive ldl cholesterol via Surviving Liver Slices (pages 17–27): Samuel Gurin and Roscoe O. Brady
Chapter five reports with Deuterium Steroids (pages 28–40): T. F. Gallagher
Chapter 6 The Biosynthetic Mechanism of Porphyrin Formation (pages 41–67): David Shemin and Jonathan Wittenberg
Chapter 7 experiences on Mammalian crimson Cells (pages 68–85): A. Neubergeb
Chapter eight initial Investigations for a learn of strength used by the Surviving chicken Erythrocyte in H?m Synthesis (pages 86–89): C. Rimington
Chapter nine Iron Metabolism in Pathological stipulations (pages 90–95): A. Vannotti
Chapter 10 The amendment of X?Ray Sensitivity by way of chemical substances (pages 96–113): Alexander Hollaender, G. E. Stapleton and W. T. Burnett
Chapter eleven impression of X?Rays on Nucleic Acid and Protein Synthesis within the Jensen Rat Sarcoma (pages 114–121): Barbara E. Holmes
Chapter 12 Radiation Dose in Tracer Experiments concerning Autoradiography (pages 122–137): S. R. Pelc
Chapter thirteen Synthesis of Deoxyribose Nucleic Acid and Nuclear Incorporation of 35S as proven by means of Autoradiographs (pages 138–151): Alma Howard and S. R. Pelc
Chapter 14 The Biosynthesis of Pyrimidines in vitro (pages 152–163): D. Wright Wilson
Chapter 15 reviews with natural? and Bio?Synthetic Nucleosides and Nucleotides (pages 164–174): G. B. Brown
Chapter sixteen using Radiophosphorus within the research of the Nucleic Acids (pages 175–183): J. N. Davidson
Chapter 17 cost of Synthesis and Quantitative diversifications of the Ribonucleic Acid through the progress of a tradition of Polytomella Coeca (pages 184–189): R. Jeener
Chapter 18 a style for the review of the speed of Protein Synthesis in guy (pages 190–202): D. Rittenberg
Chapter 19 Turnover charges in the course of Formation of Proteins and Polynucleotides in Regenerating Tissues (pages 203–212): E. Hammarsten
Chapter 20 Synthesis of Phenylalanine and Tyrosine in Yeast (pages 213–226): Konrad Bloch
Chapter 21 A research of Acetone Metabolism utilizing Glycogen and Serine as symptoms, and the position of C1?Compounds in Metabolism (pages 227–245): Harland G. Wood
Chapter 22 uneven Citric Acid (pages 246–257): Charles Heidelberger and Van R. Potter
Chapter 23 Mode of Formation of Fatty Acids from Acetate and Glucose as Studied within the Mammary Gland (pages 258–284): G. Popjak
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Extra resources for Ciba Foundation Symposium - Isotopes in Biochemistry
Sample text
University of Wisconsin Press. , HILL,B. , FIESER, L. , and RHOADS, C. P. (1948). J. biol. , 172, 263. DISCUSSION BOSCOTT: Have you studied the metabolism of estrogens? Have you ooked a t the phenolic acids, the steroid phenols? GALLAGHER: No. Dr. Dobriner has just begun some human experiments with the isotopically-labelled estrogens, but these are still in the exploratory stages. metabolism of progesterone in monkeys and chimpanzees, and I was very surprised to find that rhesus monkeys behave very differently from chimpanzees.
If labelled acetoacetate is incubated under comparable conditions with carrier non-labelled acetate, a small amount of 14C can be recovered in the isolated acetate. This recovery of 14C is much too small, however, to account for the incorporation of acetoacetate into cholesterol. Although acetate may furnish most of the carbons of cholesterol, some of it is incorporated by way of acetoacetate. It has been shown by Zabin and Bloch (1950) as well as Price and Rittenberg (1950) that [Z-l4C] acetone is converted by the rat to cholesterol and to two-carbon fragments.
Subsequent to this finding it was indeed demonstrated that both the methyl group and the carboxyl group of acetate were utilized for htem formation (Muir and Neuberger, 1950; Radin, Rittenberg and Shemin, 1950b). , 1950b). In order to determine the extent of utilization of acetate for porphyrin formation and to locate all the carbon atoms in the porphyrin which may be derived from acetate, duck blood was incubated separately with 14C methyl labelled and with 14C carboxyl labelled acetate (Shemin and Wittenberg, 1951), and the resulting labelled haemin degraded as outlined above.
Ciba Foundation Symposium - Isotopes in Biochemistry
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