By Jorge Cortes, Michael Deininger
power Myeloid Leukemia (CML) is still a key version for the enhanced realizing of the pathophysiology of a malignancy at a molecular point and has been utilized by researchers to enhance quite a few cures and healing overview tools. This concise, readable advisor assembles and synthesizes the newest advancements and traits within the therapy of CML and offers an authoritative and handy precis of the most recent growth in imatinib trials, the molecular tracking of CML responses, and the engineering of latest remedies to beat resistance and increase sufferer care.
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73. Crawley C, Szydlo R, Lalancette M, et al. Outcomes of reduced-intensity transplantation for chronic myeloid leukemia: an analysis of prognostic factors from the Chronic Leukemia Working Party of the EBMT. Blood 2005; 106:2969– 2976. 74. Laughlin MJ, Eapen M, Rubinstein P, et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 2004; 351:2265– 2275. 75. Barker JN, Weisdorf DJ, DeFor TE, et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy.
Thus, for example, a patient who after having TABLE 4 Operational Definition of Failure and Suboptimal Response for Previously Untreated, ECP, Chronic Myeloid Leukemia Patients Who Are Treated with Imatinib Mesylate 400 mg/Day Proposed by Baccarani et al. on Behalf of the European LeukemiaNet Time Diagnosis 3 months 6 months 12 months 18 months Any time Failure Suboptimal response NA NA No HR (stable disease or disease progression) Less than complete HR (CHR) No CyR (Ph-positive more than 95%) Less than PCyR (Ph-positive more than 35%) Less than CCyR Loss of CHRa Warnings High risk Del9q þ ACA in Ph-positive cells Less than CHR Less than PCyR (Ph-positive more than 35%) Less than CCyR Less than MMR ACA in Ph-positive cellsd Loss of CCyRb Loss of MMRd Mutationc Mutatione Less than MMR Any rise in transcript level Other chromosome abnormalities in Ph-negative cells Note: Failure implies that the patient should be moved to other treatments whenever available.
34. Enright H, Daniels K, Arthur DC, et al. Related donor marrow transplant for chronic myeloid leukemia: patient characteristics predictive of outcome. Bone Marrow Transplant 1996; 17:537– 542. 35. Gratwohl A, Hermans J, Goldman JM, et al. Risk assessment for patients with chronic myeloid leukaemia before allogeneic blood or marrow transplantation. Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. Lancet 1998; 352:1087– 1092. 36. Passweg JR, Walker I, Sobocinski KA, Klein JP, Horowitz MM, Giralt SA.
Chronic Myeloid Leukemia by Jorge Cortes, Michael Deininger