By Mark Cronin, Judith Madden, Steven Enoch, David Roberts, Diana Anderson
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Extra resources for Chemical Toxicity Prediction: Category Formation and Read-Across
In this category it is entirely possible that for this second endpoint chemical A may be predicted to be toxic. The explanation may be due to the relative levels of chemical reactivity required to elicit a toxicological response for the two different endpoints. A similar argument can be made as to why the absence of a structural alert designed for category formation cannot be used as an indicator for the absence of toxicity. This is due to the fact that no matter how extensive a set of View Online 14/10/2013 09:19:09.
38. D. W. Roberts and A. O. , 2009, 61, 332. 39. S. J. Enoch, D. W. Roberts and M. T. D. Cronin, Electrophilic reaction chemistry of low molecular weight respiratory sensitizers, Chem. Res. , 2009, 22, 1447. 40. S. J. Enoch, D. W. Roberts and M. T. D. Cronin, Mechanistic category formation for the prediction of respiratory sensitization, Chem. Res. , 2010, 23, 1547. 41. S. J. Enoch, M. J. Seed, D. W. Roberts, M. T. D. Cronin, S. J. Stocks and R. M. Agius, Development of mechanism-based structural alerts for respiratory sensitization hazard identification, Chem.
Enoch, J. C. Madden and M. T. D. Cronin, Integrating (Q)SAR models, expert systems and read-across approaches for the prediction of developmental toxicity, Reprod. , 2010, 30, 147. E. Hulzebos and I. Gerner, Weight factors in an Integrated Testing Strategy using adjusted OECD principles for (Q)SARs and extended Klimisch codes to decide on skin irritation classification, Regul. Toxicol. , 2010, 58, 131. E. Hulzebos, S. -P. Rila, Z. C. Dang and E. Rorije, An Integrated Assessment Scheme for assessing the adequacy of (eco)toxicological data under REACH, Toxicol.
Chemical Toxicity Prediction: Category Formation and Read-Across by Mark Cronin, Judith Madden, Steven Enoch, David Roberts, Diana Anderson
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