By Prof. Dr. J. C. Skou (auth.), Prof. Dr. Erland Erdmann, Prof. Dr. K. Greef, Prof. Dr. J. C. Skou (eds.)
The bicentenary of William Withering's now recognized scientific record entitled "An Account of the Foxglove and a few of its clinical makes use of" has given us the get together to investigate the cutting-edge. Cardiac glycosides in 1985 are thought of tobe the foundation for scientific remedy of myocardial failure, including diuretics and vasodilators within the extra serious situations. however, the talk as to their detailed position within the remedy of middle failure with sinus rhythm hasn't ever ceased. even though cardiac glycosides are of unquestionable price in tachycardia brought on by atrial traumatic inflammation or atrial flutter, the continual use of those medications in sinus rhythm isn't regularly permitted. the advance of tolerance has been suggested. it's of curiosity that Withering hirnself wrote: "-let it (foxglove) be persisted till it both acts at the kidneys, the tummy, the heart beat, or the bowels; Iet or not it's stopped upon the 1st visual appeal of any of those results, and that i will continue that the sufferer won't be afflicted by its exhibition, nor the practitioner be upset in any average expectation. " In West Germany by myself, greater than 3 million sufferers (about five% of the complete inhabitants) are continually taking cardiac glycosides. those medications are the main prescribed medicaments in lots of nations. hence, we thought of it worthy and essential to evaluate in a serious manner modern-day wisdom in regards to the foxglove; to record new findings and to guage previous Statements.
Read Online or Download Cardiac Glycosides 1785–1985: Biochemistry — Pharmacology — Clinical Relevance PDF
Similar biochemistry books
This self-contained, cutting-edge guide is designed to satisfy the wishes of the coed, skilled researcher, and newcomer to the molecular biology self-discipline looking a good technique of acquiring a clone. on hand in an easy-to-use spiral-bound variation, advisor to Molecular Cloning concepts progresses from easy innovations underlying a lot of recombinant DNA expertise to a chain of sections addressing normally met difficulties.
Because the publishing of the 1st variation, the methodologies and instrumentation curious about the sphere of mass spectrometry-based proteomics has better significantly. totally revised and extended, Mass Spectrometry facts research in Proteomics, moment variation offers specialist chapters on particular MS-based tools or information research techniques in proteomics.
Even if the idea that of allosterism has been recognized for over part a century, its program in drug discovery has exploded in recent times. The emergence of novel applied sciences that permit molecular-level ligand-receptor interactions to be studied in studied in remarkable aspect has pushed this pattern.
Extra resources for Cardiac Glycosides 1785–1985: Biochemistry — Pharmacology — Clinical Relevance
Schmiedeberg 0 (1875) Untersuchungen über die pharmakologisch wirksamen Bestandteile der Digitalis purpurea. Arch exp Path Pharmak 3: 16-43 22. ). In: Keil G (ed) Fachprosa-Studien Schmidt Berlin p 497ff 23. Schorderet M (1985) Deux centsans de digitale: 1785-1985. Med-Hyg 43: 290-295 24. Stenius R (1916) Die Geschichte der Digitalis purpurea und ihre Bedeutung in der Medizin bis etwa zum Jahre 1870. Vet med Diss Dresden 1916 25. Stenius R (1918) Die neue Geschichte der Digitalis purpurea. Arch wiss prakt Tierheilkd 44: H 5-6 26.
Pharmazie 24: 778-780 Bock H (1546) Kreuter-Buch, Strassburg fol, 335 (First edition New Kreutter Buch, Strassburg 1539) Boehm R (1872) Untersuchungen über die physiologische Wirkung der Digitalis und des Digitalin. Arch ges Physiol 5: 153-191 Darwin E (1780) An account ofthe successfull use offoxglove in some dropsies. Med Transact Roy Coll Phys London 255-286- Über die Wirkung des rothen Fingerhutes. Samml. auserl. Abb. z. Gebrauche praktischer Ärzte (1781) 6, 2 : 2 Dodoens R (1608) Cruydt-Boek.
In a Welsh-Irish herbal "Meddygon myddwai ", which was written between 1100 and 1250, the first mention of a digitalis ointment for headaches and convulsions can be found. UNGUENTUM DIGITALlS. Jt Digit~L cum toto q. f. coq. in Butyri rec. q. f. ·exprime colaturam, cui de novo adde Digitalem, ut ante; exprime denuo ad tertiam vicem~ Fiat Unguentum. Fig. 2. Unguentum Digitalis, recipe from the Pharmacopoeia Londinensis of 1721. 13 PULVIS DIALTHiEiE. Jt Rad . ficcat~ Alth~~, drachmas quinque. Glycyrhiz~ 1-fifpanic~, Offium Mefpilorum anafemiunciam.
Cardiac Glycosides 1785–1985: Biochemistry — Pharmacology — Clinical Relevance by Prof. Dr. J. C. Skou (auth.), Prof. Dr. Erland Erdmann, Prof. Dr. K. Greef, Prof. Dr. J. C. Skou (eds.)