The preeminent e-book on melanoma cytogenetics—now in a beneficial new edition
Like its profitable predecessors, Cancer Cytogenetics, 3rd variation keeps to provide authoritative insurance of neoplastic strategies on the chromosomal point of genomic association. Now up to date and increased, this re-creation contains distinct details at the most modern advances within the box, incorporating an enormous volume of latest cytogenetic in addition to molecular genetic info from the most recent easy and scientific investigations.
Edited by way of major experts, who're now aided through a panel of internationalexperts, this new version has been up to date to incorporate:
- Greatly multiplied insurance of reliable tumors
more desirable assurance of acute and persistent myeloproliferative issues
the most recent findings on acute and persistent lymphoproliferative issues
Cancer Cytogenetics, 3rd variation is a invaluable source for researchers in quite a lot of fields, together with cytogenetics, scientific and molecular genetics, mobile and molecular biology, oncology, and hematology. With its whole assurance of thecytogenetic mechanisms underlying neoplasia, and continually with a prepared eye at the medical effects of many of the bought genetic aberrations, this article is going to alsobe an vital reference for all clinicians all for the prognosis and remedy of melanoma patients.Content:
Chapter 1 a brand new method of an previous challenge (pages 1–7): Sverre Heim and Felix Mitelman
Chapter 2 Cytogenetic tools (pages 9–16): David Gisselsson
Chapter three Cytogenetic Nomenclature (pages 17–23): Sverre Heim and Felix Mitelman
Chapter four Nonrandom Chromosome Abnormalities in Cancer—An review (pages 25–43): Sverre Helm and Felix Mitelman
Chapter five Acute Myeloid Leukemia (pages 45–139): Bertil Johansson and Christine J. Harrison
Chapter 6 Myelodysplastic Syndromes (pages 141–178):
Chapter 7 continual Myeloid Leukemia (pages 179–207): Thoas Fioretos and Bertil Johansson
Chapter eight power Myeloproliferative Neoplasms (pages 209–232): Peter Vandenberghe, Lucienne Michaux and Anne Hagemeijer
Chapter nine Acute Lymphoblastic Leukemia (pages 233–296): Christine J. Harrison and Bertil Johansson
Chapter 10 Mature B? and T?cell Neoplasms and Hodgkin Lymphoma (pages 297–374): Reiner Siebert
Chapter eleven Tumors of the higher Aerodigestive Tract (pages 375–413): Mihaela Avramut and Susanne M. Gollin
Chapter 12 Tumors of the Lung (pages 415–428): Penny Nymark, Eeva Kettunen and Sakari Knuutila
Chapter thirteen Tumors of the Digestive Tract (pages 429–461): Georgia Bardi and Sverre Helm
Chapter 14 Tumors of the Urinary Tract (pages 463–491): Paola Dal Cin and Azra H. Ligon
Chapter 15 Tumors of the Breast (pages 493–516): Manuel R. Teixeira, Nikos Pandis and Sverre Heim
Chapter sixteen Tumors of the feminine Genital Organs (pages 519–556): Francesca Micci and Sverre Heim
Chapter 17 Tumors of the Male Genital Organs (pages 557–575): Manuel R. Teixeira and Sverre Heim
Chapter 18 Tumors of Endocrine Glands (pages 577–596): Jorn Bullerdiek and David Gisselsson
Chapter 19 Tumors of the anxious procedure (pages 597–619): Aaron M. Bender, Fausto J. Rodriguez, Gobinda Sarkar and Robert B. Jenkins
Chapter 20 Tumors of the attention (pages 621–639): Karen Sisley
Chapter 21 Tumors of the outside (pages 641–653): Fredrik Mertens and Sverre Heim
Chapter 22 Tumors of Bone (pages 655–674): Fredrik Mertens and Nils Mandahl
Chapter 23 delicate Tissue Tumors (pages 675–711): Nils Mandahl and Fredrik Mertens
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Extra resources for Cancer Cytogenetics, THIRD EDITION
Am J Surg Pathol30:1546-1553. Riggi N, CironiL, ProveroP, Suva ML, Kaloulis K, Garcia-EchevemaC, HoffmannF, TrumppA, StamenkovicI (2005): Development of Ewing’s sarcomafrom primarybone marrow-derived mesenchymalprogenitorcells. Cancer Res 65:11459-I 1468. Cancer Res 66:7016-7023. YuanJ, BakalarskiCE, Villen J, KomhauserJM, Smith B, Li D, Zhou X,Gygi SP,Gu TL, PolakiewiczRD, Rush J, Comb MJ (2007): Global survey of phosphotyrosinesignaling identifiesoncogenic kinasesin lung cancer. Cell 13 1:1190-1 204.
2008). Another factor that might facilitate illegitimate recombinationin a major way is sharedsequence motifs at the chromosomebreakpoints(Aplan,2006; Povirk,2006;ZhangandRowley, 2006). Future sequencingefforts will no doubt shed light on this importantissue, includingthe relative contributionof chance to what might appearas specific aberrationinduction,as will also additionalstudies of the interphasenuclearanatomyof susceptibletargetcells. Takentogether,however,thereis little evidencefavoringany substantialimpact of specific externalor internalfactors on the genesis of nonrandomchromosomeabnormalities.
Standardpathogenetictheory holds that such changes are carcinogenic by removingtumorsuppressorgenes. 3 The chromosome aberrationsof cancer may in principle exert their effect through gain or loss of genetic material or through structural or regulatory changes brought about by relocation of chromosomal segments. , 2007). It will be exciting to learn how often gene fusions turnout to be the importantoutcome of the many deletions that have been described not only cytogenetically but also increasinglyby array-basedanalyses of genomic imbalances (Cowell and Nowak, 2003; Pinkel and Albertson, 2005; Speicher and Carter, 2005).
Cancer Cytogenetics, THIRD EDITION