By Stefan D. Anker, Akio Inui, John E. Morley, Filippo Rossi Fanelli, Daniele Scevola, Michael W. Schuster, Shing-Shing Yeh, Giovanni Mantovani
Cachexia may possibly symbolize the turn facet of the great achievements of recent drugs. the purpose of this quantity, written through world-renowned scientists, is to supply the simplest to be had facts at the pathogenesis, medical good points and healing process of cachexia, and to facilitate the certainty of the complicated but unequivocal scientific function of this syndrome, that really represents a illness, or, much more likely, a ailment inside different various illnesses.
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Additional resources for Cachexia and Wasting: A Modern Approach
Hips - An LFP may be found in the hips, limited by the 12th rib above, the muscles of the lumbar region posteriorly, the abdominal muscles anteriorly, and the iliac crest below. Gluteal region and flank - The lumbo-gluteal adipose body (LGAB) has been identified in this area [12–14]. It is a symmetrical structure, shaped as a triangular pyramid, with a subcutaneous posterior base and an intermuscular anterior apex, which partially borders three regions: the inferior part of the lumbar region, the superior part of the gluteal region and the posterior part of the flank.
Science 269:543–546 12. Pelleymounter MA, Cullen MJ, Baker MB et al (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540–543 13. Tartaglia LA, Dembski M, Weng X et al (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263–1271 14. Lee GH, Proenca R, Montez JM et al (1996) Abnormal splicing of the leptin receptor in diabetic 19 20 Saverio Cinti 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. mice. Nature 379:632–635 Ghilardi N, Ziegler S, Wiestner A et al (1996) Defective STAT signalling by the leptin receptor in diabetic mice.
It is also found in the stroma-vascular fraction of adipose tissue . Adipocytic overexpression of the protein in cachectic mice is consistent with a role for it in the local control of lipolysis. A recent paper reporting that protein ZAG stimulates adiponectin expression in adipocytes in vitro suggests that it may be a gene for body weight regulation. References 1. Rothwell NJ, Stock MJ (1979) A role for brown adipose tissue in diet-induced thermogenesis. Nature 281:31–35 2. Nedergaard J, Lindberg O (1982) The brown fat cell.
Cachexia and Wasting: A Modern Approach by Stefan D. Anker, Akio Inui, John E. Morley, Filippo Rossi Fanelli, Daniele Scevola, Michael W. Schuster, Shing-Shing Yeh, Giovanni Mantovani