By James R. Berenson
Professional physicians and scientific researchers summarize and clarify all of the contemporary advances within the biology and remedy of bone marrow-based malignancy. at the organic facet, the authors express the features of the malignant cellphone and describe the numerous roles performed by means of oncogenic alterations, chromosomal anomalies, Kaposi's sarcoma herpes virus, and cytokines. New epidemiological findings and prognostic components also are analyzed. at the scientific part, the authors offer a finished evaluation of traditional remedy regimens, in addition to a dialogue of more moderen experimental ways regarding immunologic focusing on, inhibitors of drug resistance, and antitumor brokers.
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Extra info for Biology and Management of Multiple Myeloma (Current Clinical Oncology)
Using a Cµ primer with a myeloma specific CDR2 primer, pre-class switch cells that demonstrated a CDR3 sequence identical to those seen in the myeloma clone were found in the bone marrow and blood of patients with myeloma. Similar results were obtained using a patient-specific CDR3 primer with a Cµ primer and polymerase chain reaction (PCR). From these findings, it seems likely that a pre-class switch clone persists in many patients with MM. In an attempt to quantify these cells, our group sought to find them by using colony hybridization techniques.
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Biology and Management of Multiple Myeloma (Current Clinical Oncology) by James R. Berenson