By Claus-Wilhelm von der Lieth, Thomas Luetteke, Martin Frank
This publication is the 1st to be devoted to the bioinformatics of carbohydrates and glycoproteins. It offers an advent to this rising box of technology either for the experimentalist operating in glycobiology and glycomics, and likewise for the pc scientist trying to find heritage info for the improvement of hugely refined algorithmic approaches. The publication offers an outline of the state of the art within the box, with stories on databases, and the instruments in use for research, interpretation, and prediction of the buildings of advanced carbohydrates, and demonstrates the price of bioinformatics for glycobiology.
the provision of accomplished databases and corresponding bioinformatics instruments, to entry and examine the massive quantities of experimental facts with regards to the constitution of carbohydrates, could be a prerequisite for the luck of the large-scale glycomics initiatives that goal to decipher new, thus far unknown, organic features of glycans. Efficient bioinformatics descriptions and instruments can significantly increase the potency of glycomics learn, when it comes to facts caliber, research and experimental charges.
for an entire figuring out of the molecular strategies during which carbohydrates are concerned, corresponding to protein–carbohydrate interactions and the impression of glycosylation on protein functionality, wisdom of the 3D constitution of the carbohydrate, the protein–carbohydrate advanced, or the glycoprotein is usually fundamental. This e-book offers a radical advent into tools used for conformational research of carbohydrates.
Key positive factors:
- Describes bioinformatic ways to address carbohydrate-active enzymes and glycosylation.
- Provides an outline on bioinformatics instruments that facilitate research of carbohydrate buildings.
- Gives advent into molecular modelling of carbohydrate 3D constitution and carbohydrates inside the Protein Databank.
- Assumes just a simple wisdom of biology and bioinformatics.
Read Online or Download Bioinformatics for Glycobiology and Glycomics: An Introduction PDF
Best bioinformatics books
Because the autonomous invention of DNA sequencing through Sanger and by way of Gilbert 30 years in the past, it has grown from a small scale method able to examining numerous kilobase-pair of series in step with day into trendy multibillion buck undefined. This development has spurred the improvement of recent sequencing applied sciences that don't contain both electrophoresis or Sanger sequencing chemistries.
Content material: bankruptcy 1 the invention of Transposition (pages 3–13): Nina V. FedoroffChapter 2 A box consultant to Transposable parts (pages 15–40): Alan H. Schulman and Thomas WickerChapter three The Mechanism of Ac/Ds Transposition (pages 41–59): Thomas Peterson and Jianbo ZhangChapter four McClintock and Epigenetics (pages 61–70): Nina V.
This quantity deals a huge and interdisciplinary view of recent methods to drug discovery as utilized by pharmaceutical businesses and learn institutes. It comprehensively covers proteomics, bioinformatics, screening thoughts similar to high-throughput-, common compounds-, and NMR-based-screenings, combinatorial chemistry, compound library layout, ligand- and structure-based drug layout and pharmacokinetic ways.
Der renommierte Tierphysiologe Heinz Penzlin behandelt in diesem Buch, das hier in zweiter Auflage vorgelegt wird, in systematischer und übersichtlicher shape die naturwissenschaftlichen Grundprinzipien, die alleLebewesen – trotz ihrer enormen Formenvielfalt – gleichermaßen kennzeichnen. Das Buch ist keine Biophilosophie, sondern richtet sich an alle, die an den wissenschaftlichen Grundlagen des Phänomens „Leben“ aus heutiger Sicht interessiert sind.
Additional info for Bioinformatics for Glycobiology and Glycomics: An Introduction
Schofield L, Hewitt MC, Evans K, Siomos M-A, Seeberger PH: Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria. Nature 2002, 418:785–789. 57. Vansteenkiste J, Rossi G, Foote M: Darbepoetin alfa: a new approach to the treatment of chemotherapy-induced anaemia. Expert Opin Biol Ther 2003, 3:501–508. 58. Doubet S, Bock K, Smith D, Darvill A, Albersheim P: The Complex Carbohydrate Structure Database. Trends Biochem Sci 1989, 14:475–477. 59. Doubet S, Albersheim P: CarbBank. Glycobiology 1992, 2:505.
At the end of the 1990s, an American research team was able to detect fragments of the viral genome in lung samples taken from the body of an Inuit woman victim of 1 Glycobiology, Glycomics and (Bio)Informatics 11 the pandemic buried in the Alaskan tundra and a number of preserved samples taken from American soldiers of the First World War. Using modern biomolecular amplification techniques, the entire coding sequence of 1701 nucleotides for the viral surface HA was amplified in 22 overlapping fragments such that the sequences for matching primers could be confirmed .
Glycan microarrays are a relatively new and highly specific technology that allows rapid determination of glycan-binding protein interactions and specificities. Subsequently it was shown  that a single amino acid substitution in the 1918 human influenza virus HA – Asp225 to Gly – changes receptor binding specificity from an HA which preferentially binds to the human ␣2,6-sialylgalactose motif to one which binds both the human ␣2,6- and the ␣2,3-sialylgalactose motif of the avian cellular receptors.
Bioinformatics for Glycobiology and Glycomics: An Introduction by Claus-Wilhelm von der Lieth, Thomas Luetteke, Martin Frank