By Jonathan Pevsner
ISBN-10: 0471210048
ISBN-13: 9780471210047
The bestselling creation to bioinformatics and useful genomics. Bioinformatics and useful Genomics bargains the main broad-based advent to this explosive new self-discipline.
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Additional info for Bioinformatics and Functional Genomics
Sample text
The central dogma of molecular biology is that DNA is transcribed into RNA and translated into protein. The focus of molechular biology has been on individual genes, messenger RNA (mRNA) transcripts, and proteins. A focus of the field of bioinformatics is the complete collection of DNA (the genome), RNA (the transcriptome), and protein sequences (the proteome) that have been amassed (Henikoff, 2002). These millions of molecular sequences present both great opportunities and great challenges. A bioinformatics approach to molecular sequence data involves the application of computer algorithms and computer databases to molecular and cellular biology.
While the sequence information underlying DDBJ, EBI, and GenBank are equivalent, we begin our discussion with GenBank. , 2002). In addition to storing these sequences, GenBank contains bibliographic and biological annotation. , 2002). 1. nlm. 0, April 2003). 1. Over the period 1982 to the present, the number of bases in GenBank has doubled approximately every 14 months. , 2002). 1. We will define the bacteria, archaea, and eukaryotes in detail in Chapters 14-16. gov/Taxonomy/. Between October 2001 and October 2002, over 12 billion base pairs (bp) of DNA were added to GenBank, an average of 33 million bp per day.
Html, February 2003. 5. gov). Across the top bar, sections include PubMed, Entrez and Books (described in this chapter), BLAST (Chapters 3-5), Taxonomj (Chapters 12-1 7), Structure (Chapter 9), and Online Mendelian Inheritance in Man (OMIM, Chapter 18). Note that the left sidebar includes tutorials within the Education section. , 1990,1997). BLAST is a set of similarity search programs designed to explore all of the available sequence databases regardless of whether the query is protein or DNA.
Bioinformatics and Functional Genomics by Jonathan Pevsner
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