By Gerhard Krauss
This all-new version of a best-selling textual content has been completely up to date to maintain speed with the swift development in sign transduction research.
With didactic ability and readability, the molecular foundation of sign transduction, regulated gene expression, the cellphone cycle, tumorigenesis and apoptosis is made obvious for everybody with a easy wisdom in biochemistry or molecular biology.
"Valuable updated info on biochemistry of sign transduction and regulation" (AFS)
"The transparent and didactic presentation makes it a textbook very worthy for college students and researchers now not accustomed to all features of cellphone regulation." (Biochemistry)
"This publication is basically books: legislation and sign Transduction." (Drug Research)
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Extra info for Biochemistry of Signal Transduction and Regulation
Coli is shown in Fig. 9. The DNA is contacted in the major groove by the protruding g -strands. The eukaryotic transcription factor NF O B also binds DNA via g -sheet structure (Fig. 10). Noteworthy is the enshrouding of the DNA by the g -sheets of NF O B. The recognition of the DNA elements is also achieved by interaction with the major groove of the DNA. 5 Flexible Structures in DNA-binding Proteins A series of DNA-binding proteins utilize additional flexible structures aside from defined structural DNA-binding motifs in order to increase the stability and specificity of the complex.
The recognition of the DNA sequence occurs via this § -helix. A very similar zinc finger is found in Zif268, a regulatory DNA-binding protein of mice (Pavletich and Pabo, 1991). The structure of the Zif268-DNA complex is shown in Fig. 5. In Zif268, three of the zinc-fingers are arranged along the coil of the DNA. The DNA-binding element contains three repeats of the recognition sequence. This results in a modular construction of the protein, so that the periodicity of the DNA is reflected in the protein structure.
14). g. dA5) leads to an intrinsic bending of the DNA by ca. 18°. If the dA-repeats in the sequence are properly arranged, then a definite bending of the DNA results. The intrinsic bending of DNA is easily detectable by gel electrophoresis: a bent DNA migrates in a native electrophoresis slower than a linear DNA of the same length. Fig. 14. Intrinsic bending of DNA via periodic repeat of (dA)5–6 sequences. An intrinsic bending of DNA of ca. 18° is induced per (dA)5–6 sequence. Poly-dA repeats in 10 bp steps (the rise of the DNA) result in a strong bending of the DNA, since in this configuration the axis of bending lies on the same side of the DNA.
Biochemistry of Signal Transduction and Regulation by Gerhard Krauss