By Dennis E Vance
Examine at the biochemistry and molecular biology of lipids and lipoproteins has skilled striking development within the final twenty years, really with the belief that many various periods of lipids play basic roles in ailments comparable to middle illness, weight problems, diabetes, melanoma and neurodegenerative issues. The fifth variation of this e-book has been written with significant pursuits. the 1st goal is to supply scholars and academics with a sophisticated up to date textbook protecting the main components of present curiosity within the lipid box. The chapters are written for college students and researchers conversant in the overall ideas of lipid metabolism yet who desire to extend their wisdom during this region. the second one target is to supply a reference textual content for scientists who're approximately to go into the sphere of lipids, lipoproteins and membranes and who desire to research extra approximately this quarter of analysis. all the chapters were greatly up-to-date because the 4th version seemed in 2002. Key positive factors: * Represents a bridge among the superficial assurance of the lipid box present in simple biochemistry textual content books and the hugely really expert fabric contained in medical evaluate articles and monographs. * permits scientists to familiarize yourself with contemporary advancements regarding their very own learn pursuits, and should aid scientific researchers and scientific scholars retain abreast of advancements in simple technology which are vital for next medical advances. * Serves as a basic reference ebook for scientists learning lipids, lipoproteins and membranes and as a complicated and updated textbook for academics and scholars who're accustomed to the fundamental techniques of lipid biochemistry learn more... content material: sensible roles of lipids in membranes / William Dowhan, Mikhail Bogdanov, and Eugenia Mileykovskaya -- Lipid variations of proteins / Anant ok. Menon -- Fatty acid and phospholipid metabolism in prokaryotes / Charles O. Rock -- Lipid metabolism in vegetation / Katherine M. Schmid and John B. Ohlrogge -- Oxidation of fatty acids in eukaryotes / Horst Schulz -- Fatty acid synthesis in eukaryotes / Hei Sook Sul and Stuart Smith -- Fatty acid desaturation and chain elongation in mammals / Makoto Miyazaki and James M. Ntambi -- Phospholipid biosynthesis in eukaryotes / Dennis E. Vance and Jean E. Vance -- Ether-linked lipids and their bioactive species / Thomas M. McIntyre, Fred Snyder, and Gopal ok. Marathe -- Lipid metabolism in adipose tissue / Ann V. Hertzel ... [et al.] -- Phospholipases / David C. Wilton -- The eicosanoids : cyclooxygenase, lipoxygenase, and epoxygenase pathways / William L. Smith and Robert C. Murphy -- Sphingolipids / Alfred H. Merrill, Jr. -- ldl cholesterol biosynthesis / Laura Liscum -- Metabolism and serve as of bile acids / Luis B. Agellon -- Lipid meeting into phone membranes / Dennis R. Voelker -- Lipoprotein constitution / Ana Jonas and Michael C. Phillips -- meeting and secretion of triacylglycerol-rich lipoproteins / Jean E. Vance and Khosrow Adeli -- Dynamics of lipoprotein shipping within the circulatory procedure / Christopher J. Fielding and Phoebe E. Fielding -- Lipoprotein receptors / Wolfgang J. Schneider -- Lipids and atherosclerosis / Ira Tabas. summary: study at the biochemistry and molecular biology of lipids and lipoproteins has skilled outstanding progress within the final twenty years, rather with the conclusion that many alternative periods of lipids play primary roles in illnesses akin to middle illness, weight problems, diabetes, melanoma and neurodegenerative problems. The fifth version of this e-book has been written with significant pursuits. the 1st goal is to supply scholars and academics with a sophisticated up to date textbook protecting the main components of present curiosity within the lipid box. The chapters are written for college students and researchers conversant in the final innovations of lipid metabolism yet who desire to extend their wisdom during this quarter. the second one target is to supply a reference textual content for scientists who're approximately to go into the sphere of lipids, lipoproteins and membranes and who desire to examine extra approximately this zone of analysis. the entire chapters were broadly up to date because the 4th version seemed in 2002. Key gains: * Represents a bridge among the superficial insurance of the lipid box present in simple biochemistry textual content books and the hugely really expert fabric contained in clinical assessment articles and monographs. * permits scientists to familiarize yourself with contemporary advancements on the topic of their very own learn pursuits, and may support scientific researchers and clinical scholars hold abreast of advancements in easy technological know-how which are very important for next scientific advances. * Serves as a normal reference publication for scientists learning lipids, lipoproteins and membranes and as a sophisticated and updated textbook for lecturers and scholars who're accustomed to the elemental techniques of lipid biochemistry
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Additional info for Biochemistry of lipids, lipoproteins and membranes : (5th edn.)
The use of lipids as interface material reduces the need for highly complementary protein–protein interactions and provides flexible interactions between subunits. 4. Supermolecular complex formation Kinetic and structural analysis of the mammalian mitochondrial respiratory chain suggested that its individual Complexes I–IV (NADH dehydrogenase, succinate dehydrogenase, bc1 complex, and cytochrome c oxidase, respectively) physiologically exist in equilibrium with supermolecular complexes or ‘respirasomes’ composed of the individual complexes .
Coli are organized as antiparallel chains forming a barrel structure with an internal aqueous pore and an exterior hydrophobic interface with the membrane bilayer (Fig. 10C). The X-ray crystal structure of E. coli outer membrane ferric hydroxamate uptake receptor (FhuA) contains bound lipopolysaccharide in 1:1 stoichiometric amounts . The acyl chains of the lipopolysaccharide are ordered on the protein surface approximately parallel to the axis of the -barrel along the half of the hydrophobic belt oriented toward the extracellular surface of the outer membrane.
When binding occurs via two positively charged amphipathic helices, a large structural change occurs leading to enzyme activation. Affinity for an anionic membrane surface is understandable, but the role of other lipids such as PE and diacylglycerol in activation and the negative effect of fatty acids have only been recently clarified . The former two non-bilayer-forming lipids induce a negative curvature of the two halves of the bilayer toward the aqueous domain and away from the hydrophobic domain.
Biochemistry of lipids, lipoproteins and membranes : (5th edn.) by Dennis E Vance