By Oscar Bodansky
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At various stages of metastatic carcinoma of the breast, the activity could rise as high as 200-400 units. An impressive degree of correlation was found, in general, to exist between increases in this serum enzyme activity and growth of metastatic tumor in bone, as judged clinically and by biochemical methods, particularly by the determination of urinary excretion of calcium. The serum glucosephosphate isomerase activity was also elevated, sometimes quite considerably, in metastatic growth of breast cancer in the liver when the urinary excretion of calcium could not be expected to be, and was not, affected appreciably.
Similar exceptions to Warburg's generalization have been observed by other investigators (Dickens and Weil-Malherbe, 1936, 1941). In spite of the discrepancies that we have just described, the question naturally arises whether the general tenor of Warburg's in vitro findings apply in vivo. Even preceding the in vitro findings, Cori and Cori (1925a) noted that oral, intraperitoneal, or subcutaneous administration of glucose to rats with Jensen sarcoma or to mice with spontaneous mammary carcinoma markedly increased the lactic acid concentration of the tumors.
Although the elevation of glucosephosphate isomerase activity in the serum is not specific for the presence of cancer, the extent of elevation of this enzyme activity is a fairly good criterion of the progress of neoplastic disease and, as we shall point out later, is more sensitive than other serum enzyme elevations in revealing changes in the clinical status of the cancer patient. 3. 13), was found by Meyerhof and Lohmann (1934) in muscle and yeast extracts. It mediates the reversible cleavage of fructose 1,6-diphosphate between C-3 and C-4 to yield dihydroxyacetone phosphate and D-glyceraldehyde3-phosphate.
Biochemistry of Human Cancer by Oscar Bodansky