By Neal E. Artz, Elizabeth M. Osman
ISBN-10: 1483200418
ISBN-13: 9781483200415
Read Online or Download Biochemistry of Glucuronic Acid PDF
Best biochemistry books
Shelby L. Berger, Alan R. Kimmel's Guide to Molecular Cloning Techniques PDF
This self-contained, state of the art handbook is designed to satisfy the desires of the coed, skilled researcher, and newcomer to the molecular biology self-discipline looking a good technique of acquiring a clone. on hand in an easy-to-use spiral-bound version, advisor to Molecular Cloning innovations progresses from simple thoughts underlying a lot of recombinant DNA know-how to a sequence of sections addressing as a rule met difficulties.
Read e-book online Mass Spectrometry Data Analysis in Proteomics PDF
Because the publishing of the 1st version, the methodologies and instrumentation interested by the sector of mass spectrometry-based proteomics has stronger significantly. absolutely revised and accelerated, Mass Spectrometry facts research in Proteomics, moment version offers specialist chapters on particular MS-based equipment or information research options in proteomics.
Allosterism in drug discovery by Dario Doller, David Thurston, David Rotella, Terry Kenakin, PDF
Even though the idea that of allosterism has been identified for over part a century, its program in drug discovery has exploded in recent times. The emergence of novel applied sciences that permit molecular-level ligand-receptor interactions to be studied in studied in exceptional element has pushed this development.
Extra resources for Biochemistry of Glucuronic Acid
Example text
Furthermore, although these investigators conclude that the uronic acid in the liver of adult rabbits is probably galacturonic acid because the animal is herbivorous and ingests a diet containing pectic substances rather than mucin, Williams (443) reports the isolation of 40 g. of glucuronolactone for each 100 g. of menthol fed to rabbits, indicating that the uronic acid excreted must be largely glucuronic. It also has been reported by Werch and Ivy (436) that less than 10 per cent, if any, of the galacturonic acid introduced as an isosmotic and isotonic solution is absorbed from the canine or human intestine.
Glycine conjugation or hippuric acid synthesis 4. cysteine conjugation or mercapturic acid synthesis 5. ornithine conjugation or ornithuric acid synthesis 6. glutamine conjugation 7. acetylation 8. methylation 9. thiocyanate detoxication Not all of these mechanisms are possible for all animal species and, more important, not all of them actually result in reduced toxicity when they occur. Glucuronic acid conjugation is by far the most common of these syntheses. It has been found to occur in all species studied, and appears to result in a reduction in toxicity and greatly increased solubility at physiological pH levels.
This was confirmed by Baeyer (13) in 1870. On the basis of the equation for formation of euxanthone from euxanthic acid, Baeyer stated that the reducing substance, which he termed "a kind of saccharic acid," should have the formula CeHio07, which now is known to be correct for glucuronic acid. Mering and Musculus (258) in 1875 observed that, following ingestion of chloral hydrate, man excreted in the urine a compound which is strongly acidic, copper-reducing and levorotatory. This compound was isolated in crys35 36 BIOCHEMISTRY OF GLUCURONIC ACID talline form and named urochloralic acid.
Biochemistry of Glucuronic Acid by Neal E. Artz, Elizabeth M. Osman
by Anthony
4.5