By Denise R. Ferrier PhD
Lippincott’s Illustrated reports: Biochemistry is the common first-and top source for the necessities of biochemistry. scholars depend upon this article to assist them speedy overview, assimilate, and combine quite a lot of severe and intricate info. For greater than 20 years, college and scholars have praised LIR Biochemistry’s matchless illustrations that make options come to life.
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The re la xe d form is the high-oxyge n-a ffinity form of he moglobin. Incre a s e d O 2 a ffinity (de cre a s e d de live ry) re s ults in a le ft s hift in the O 2 -dis s ocia tion curve . De cre a s e d O 2 de live ry is compe ns a te d for by incre a s e d RBC production. In HbC, the polar glutamate is replaced by polar lysine rather than by nonpolar valine as in HbS. ir 42 3. 25 Ke y conce pt ma p for he moglobinopa thie s . Hb = he moglobin. 6 A 67-year-old man presented to the emergency department with a 1-week history of angina and shortness of breath.
It ha s a cons tra ine d s tructure tha t limits the move me nt of the polype ptide cha ins . The T form is the lo w-o xyg e n-affinity fo rm of Hb. The binding of O 2 to Hb ca us e s rupture of s ome of the ionic a nd hydroge n bonds , a nd move me nt of the dime rs . This le a ds to a s tructure ca lle d the “R,” or re laxe d c o nfo rmatio n . The R form is the hig h-o xyg e naffinity fo rm of Hb. The o xyg e n-dis s o c iatio n c urve for Hb is s ig mo idal in s ha pe (in contra s t to tha t of myo g lo bin , which is hype rbo lic ), indica ting tha t the s ubunits coope ra te in binding O 2 .
E . Ro le o f 2,3-BPG in trans fus e d blo o d: 2,3-BP G is e s s e ntia l for the norma l oxyge n tra ns port function of he moglobin. Howe ve r, s toring blood in the curre ntly a va ila ble me dia re s ults in a de cre a s e in 2,3-BP G. S tore d blood dis pla ys a n a bnorma lly high oxyge n a ffinity a nd fa ils to unloa d its bound oxyge n prope rly in the tis s ue s . He moglobin de ficie nt in 2,3-BP G thus a cts a s a n oxyge n “tra p” ra the r tha n a s a n oxyge n tra ns port s ys te m.
Biochemistry (Lippincott Illustrated Reviews Series), 6th edition by Denise R. Ferrier PhD