By G.O. Evans
Hematology facts from in vivo toxicology reports continues to be one among the main predictive measures for human threat, because the related measurements made in pre-clinical toxicology experiences should be made in early medical trials.
Covering the 3 major blood cellphone varieties – erythrocytes, leukocytes and thrombocytes, this paintings is designed to explain subject matters for brand new entrants to the fields of laboratory animal hematology and toxicology, in particular these subject matters the place the principles for human hematology don't continually observe. a complete bankruptcy is dedicated to immunotoxicology, a systematic self-discipline that's heavily aligned with hematology.
The textual content additionally addresses pre-analytical and analytical variables that impact animal reports, as those play a much more vital half whilst studying information not like people the place a lot of those variables will be good managed or have much less physiological impact. details has been collated from released papers, textbooks and unpublished info: Readers are supplied with key references to inspire additional research
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Extra resources for Animal Hematotoxicology: A Practical Guide for Toxicologists and Biomedical Researchers
Among the causes of intravascular hemolysis, which leads to increased plasma hemoglobin and hematuria, is hemolysis that may occur with intravenous injections when either the vehicle or xenobiotic alters the integrity of the red cell (see Chapter 4 for in vitro testing for hemolysis). , excessive centrifugation, contamination of plasma/serum with red cells at separation, or other sample processing problems. Where hemoglobin breakdown occurs due to intravascular or extravascular hemolysis, it is possible to further identify the underlying mechanisms, and that these anemias are regenerative with the bone marrow compensating by increasing erythropoiesis.
Health Perspect. 106 (Suppl. 2):541–47. Parchment, R. , and Erickson-Miller, C. l. 1993. Roles for in vitro myelotoxicity tests in preclinical drug development and clinical trial planning. Toxicol. Pathol. 21:241–50. , and Yoshida, C. 1990. Reversal of azidothymidine-induced bone marrow suppression by 2’,3’-dideoxythymidine as studied by hemopoietic clonal culture. Aids Res. Hum. Retroviruses 6:929–32. indb 22 6/24/08 5:26:44 AM 3 Erythrocytes, Anemias, and Polycythemias A simplified description of erythropoiesis is given in Chapter 2.
33:58–67. Brown, G. 1991. The left shift index: A useful guide to interpretation of marrow data. Comp. Haematol. Int. 1:106–11. indb 20 6/24/08 5:26:43 AM Hemopoiesis, Blood Cell Types, and Bone Marrow Examination 21 Clark, R. , and Korst, D. R. 1969. Circadian periodicity of bone marrow, mitotic activity and reticulocyte counts in rats and mice. Science 166:236–37. Criswell, K. , Bleavins, M. , and Zandee, J. C. 1998. Comparison of flow cytometric and manual bone marrow differentials in Wistar rats.
Animal Hematotoxicology: A Practical Guide for Toxicologists and Biomedical Researchers by G.O. Evans