By Trevor M. Penning, J. Mark Petrash
content material: part 1: normal assessment ; 1. creation and assessment of the Aldo-Keto Reductase (AKR) Superfamily ; part 2: AKRS AND ENDOGENOUS TOXICANTS ; 2. Aldo-Keto Reductase-Catalyzed Detoxication of Endogenous Aldehydes linked to Diabetic issues ; three. Aldose Reductase Detoxifies Lipid Aldehydes and Their Glutathione Conjugates ; four. position of Aldose Reductase within the cleansing of Oxidized Phospholipids ; part three: AKRS AND EXOGENOUS TOXICANTS: TOBACCO similar cancer causing agents ; five. Competing Roles of Reductases within the detoxing of the Tobacco-Specific Nitrosamine Ketone NNK ; 6. Aldo-Keto Reductases and the Metabolic Activation of Polycyclic fragrant Hydrocarbons ; 7. Molecular Cloning and Characterization of Dihydrodiol Dehydrogenase from Mouse ; eight effective Synthesis of the lively Metabolites of Carcinogenic Polycyclic fragrant Hydrocarbons ; nine. Chemistry of PAH o-Quinones Generated by way of the AKR Pathway of PAH Activation ; 10. research of Etheno-2'-Deoxyguanosine Adducts as Dosimeters of AKR Mediated Oxidative tension ; part four: AKRS AND EXOGENOUS TOXICANTS: MYCOTOXINS, ALDEHYDES AND KETONES ; eleven. Aflatoxin Aldehyde Reductases ; 12. Competing Reactions of Aflatoxin B1-Dialdehyde: Enzymatic relief vs Adduction with Lysine ; thirteen. using mammalian mobilephone traces to enquire the position of aldo-keto reductases within the detoxication of aldehydes and ketones ; part five: AKRS, the tension reaction AND phone SIGNALING ; 14. Aldose Reductase and the tension reaction ; 15. Aldose Reductase Regulates Reactive Oxygen Species Mediated-Inflammatory signs ; sixteen. Aldo-Keto Reductases within the pressure reaction of the Budding Yeast Saccharomyces cerevisiae
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Extra resources for Aldo-Keto Reductases and Toxicant Metabolism
The chain length of the aldehyde remaining esterified could also vary. Thus, free and esterified aldehydes with a different number of double bonds and methylene chains are formed. Among free unsaturated aldehydes generated from the peroxidation of 0-6-polyunsaturated fatty acids (arachidonate, linolinate and linolenate), 4-hydroxy ^m«5-2-nonenal (HNE) is formed in the highest concentration, and under some conditions, accounts for > 95% of alkenals produced (5). 8 /iM (4). However, under the condition of oxidative stress, the concentration of HNE in the membrane can reach up to 5 mM and the concentration of HNE in oxLDL has been estimated to be 150 mM (4).
ACS Symposium Series; American Chemical Society: Washington, DC, 2003. 54 serum. Prior to the experiment, the cells were washed with serum-free D M E M medium. The cells were incubated without or with 5^M HNE in serum-free DMEM medium at 37 °C for 1 h. The incubation medium was aspirated out, and the cells were washed with serum-free D M E M medium (to remove any adherent HNE). The cells were then stimulated with TNF-a (10 ng/ml) for 24 h in D M E M medium containing 10% fetal calf serum. Viability of the cells appeared normal after treatment.
Proc. Natl. Acad. Sci. USA 1985 82, 7222-72226. 14. ; Srivastava, S. K. Diabetes 1985, 34, 1145-1151. 15. Srivastava, S. ; Petrash, J. ; Sadana, I. ; Ansari, N . ; Partridge, C. A. Curr. Eye Res. 1983, 2, 407-410. 16. ; Boss, G. ; Lane, M . F. 1987 Diabetologia 30, 222-227. 17. ; Ansari, N. ; Srivastava, S. K. Biochem. Pharmacol. 1990, 39, 1115-1124. 18. ; Srivastava, S. K. Biochem. Pharmacol. 1992, 44, 2427-2429. 19. ; Srivastava, S. K. Mol. Pharmacol. 1989, 36, 825-830. 20. ; Srivastava, S. K.
Aldo-Keto Reductases and Toxicant Metabolism by Trevor M. Penning, J. Mark Petrash